Sparfloxacin

SKU: orb1226976

Description

Sparfloxacin is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription.(In Vitro):Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis.

Key Properties

• CAS Number: 110871-86-8
• MW: 392.4
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₂F₂N₄O₃
• SMILES: O=C(C1=CN(C2CC2)C3=C(C(N)=C(F)C(N4C[C@H](C)N[C@H](C)C4)=C3F)C1=O)O
• Target: DNA gyrase
• Solubility: DMSO: 9 mg/mL (22.93 mM)

Bioactivity

• In Vitro:
  Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against Gram-positive organisms, such as members of the genera Staphylococcus, Streptococcus and Enterococcus, and 0.0125 to 1.56 μg/ml against Gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona. Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa in mice. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AT-4140 | CI-978 | CP 103,826 | PD 1315-1 | PD 131501

Quick Database Links

Gene Symbol

DNA gyrase