Sophocarpine

SKU: orb1300564

Description

Sophocarpine is a multi-functional small molecule with demonstrated anti-cancer, anti-inflammatory, and hepatoprotective activities in research models. Its application in studying osteolytic diseases is supported by evidence showing it inhibits osteoclast formation and bone resorption, potentially addressing prosthesis loosening.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 6483-15-4
• MW: 246.35
• Purity: 99.89%
• Formula: C₁₅H₂₂N₂O
• SMILES: [H][C@]12CCCN3CCC[C@]([H])([C@@]4([H])CC=CC(=O)N4C1)[C@]23[H]
• Target: Akt,PI3K,COX,MEK,STAT,ERK,p38 MAPK,NF-κB,Apoptosis,TLR,Potassium Channel,Autophagy,JNK,Influenza Virus,PTEN
• Solubility: Ethanol:49 mg/mL (198.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM);H2O:5 mg/mL (20.3 mM);DMSO:49 mg/mL (198.9 mM)

Bioactivity

• In Vivo:
  Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94 mg/kg (i.v.)
• In Vitro:
  Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Apoptosis, Autophagy, NF-κB, NFκB, NFkB, NF-kB, Influenza Virus, JNK, inhibit, ERK, Inhibitor, IFN-γ, hERG, p38MAPK, p38 MAPK, PotassiumChannel, Potassium Channel, TLR, Phosphoinositide 3-kinase, PI3K, PKB, Protein kinase B, Sophocarpine, STAT

Compound Identifiers

PubChem CID

115269