Sophocarpine monohydrate

SKU: orb1305081

Description

Sophocarpine monohydrate is a key bioactive alkaloid isolated from Sophora alopecuroides. It exhibits diverse pharmacological activities and is widely used in research areas such as inflammation, cancer, and fibrosis, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 145572-44-7
• MW: 246.35
• Purity: 99.55% (May vary between batches)
• Formula: C₁₅H₂₂N₂O
• SMILES: O.O=C1C=CC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@@H]34
• Target: Akt,PI3K,MEK,AMPK,ERK,NF-κB,Apoptosis,Autophagy,Influenza Virus
• Solubility: DMSO:60 mg/mL (243.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM)

Bioactivity

• In Vivo:
  Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94 mg/kg (i.v.)
• In Vitro:
  Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Autophagy, Apoptosis, AMPK, InfluenzaVirus, Influenza Virus, PI3K, Sophocarpine, Sophocarpine hydrate

Compound Identifiers

PubChem CID

71748607