Solamargine

SKU: orb1303274

Description

Solamargine

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 20311-51-7
• MW: 868.06
• Purity: 99.96% (May vary between batches)
• Formula: C₄₅H₇₃NO₁₅
• SMILES: C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@H]2O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O[C@]11CC[C@@H](C)CN1
• Target: STAT,p38 MAPK,Apoptosis,P-gp
• Solubility: DMSO:127.5 mg/mL (146.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.8 mM)

Bioactivity

• In Vitro:
  Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P-glycoprotein, P-gp (P-glycoprotein), P-gp, Pgp, STAT3, Solamargin, Solamargine, δ-Solanigrine, Cluster of differentiation 243, cells, CD243, cytotoxicity, delta-Solanigrine, ABCB1, Apoptosis, cancer, p38 MAPK, p38MAPK, inhibit, Multidrug resistance protein 1, Inhibitor, gastric, HepG2, MDR1

Compound Identifiers

PubChem CID

73611