Solamargine

SKU: orb1223197

Description

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.

Key Properties

• CAS Number: 20311-51-7
• MW: 868.07
• Purity: >98% (HPLC)
• Formula: C₄₅H₇₃NO₁₅
• SMILES: [C@H]1([C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)NC[C@@H](CC6)C)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)CO
• Target: PKC
• Solubility: DMSO : ≥ 8.8 mg/mL; 10.14 mM

Bioactivity

• In Vivo:
  Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC In vivo. Animal model: Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old). Dosage: 10 mg/kg. Administration: Intragastric administration; once daily for 8 days. Result: Tumor growth was significantly inhibited.
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• In Vitro:
  Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis. Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell line: SMMC-7721cells. Concentration: 15 μg/ml. Incubation time: 72 hours. Result: Displayed a significant increase of sub-G1.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Solamargin | δ-Solanigrine

Quick Database Links

Gene Symbol

PKC