Sodium Tetradecyl Sulfate

SKU: orb1940167

Description

Sodium Tetradecyl Sulfate is a detergent sclerosant with antithrombotic effects and commonly used for the treatment of varicose veins.(In Vitro):Proteins C, S and antithrombin (AT) were assayed in normal plasma treated with increasing concentrations of Sodium Tetradecyl Sulfate. High concentration (>0.6%) Sodium Tetradecyl Sulfate significantly destroyed proteins C, S and AT. Sodium Tetradecyl Sulfate potentiated the anticoagulant effect of APC. Sodium Tetradecyl Sulfate mimicked AT and demonstrated significant anti-Xa and anti-IIa activity. STS demonstrated a weak anticoagulant profile to heparin. It also significantly potentiated the anticoagulant effect of heparin.(In Vivo):i.v. + p.v. injection of Sodium Tetradecyl Sulfate and hydroxy polyethoxy dodecan provided a high degree of efficacy as regards vein occlusion. On the other hand, i.v. + p.v. injection induced a severe inflammation and necrosis of the tissues surrounding the sclerosed vein.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1191-50-0
• MW: 316.43
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₉NaO₄S
• SMILES: [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O
• Target: NMDA
• Solubility: In Vitro: DMSO : 100 mg/mL (316.03 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tetradecyl sodiuM sulfate

Quick Database Links

Gene Symbol

NMDA