Sodium Tetradecyl Sulfate

SKU: orb1297975

Description

Sodium Tetradecyl Sulfate is a synthetic detergent and sclerosing agent used in research to model venous disease and study thrombosis. Its antithrombotic and endothelial-disrupting properties make it valuable for in vitro hemolysis studies and in vivo models of vascular sclerosis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1191-50-0
• MW: 316.432
• Purity: 99.85% (May vary between batches)
• Formula: C₁₄H₂₉NaO₄S
• SMILES: O=S(OCCCCCCCCCCCCCC)([O-])=O.[Na+]
• Target: Others
• Solubility: DMSO:65 mg/mL (205.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.32 mM)

Bioactivity

• In Vivo:
  i.v. + p.v. injection of Sodium Tetradecyl Sulfate and hydroxy polyethoxy dodecan provided a high degree of efficacy as regards vein occlusion. On the other hand, i.v. + p.v. injection induced a severe inflammation and necrosis of the tissues surrounding the sclerosed vein.
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• In Vitro:
  Proteins C, S and antithrombin (AT) were assayed in normal plasma treated with increasing concentrations of Sodium Tetradecyl Sulfate. High concentration (>0.6%) Sodium Tetradecyl Sulfate significantly destroyed proteins C, S and AT. Sodium Tetradecyl Sulfate potentiated the anticoagulant effect of APC. Sodium Tetradecyl Sulfate mimicked AT and demonstrated significant anti-Xa and anti-IIa activity. STS demonstrated a weak anticoagulant profile to heparin. It also significantly potentiated the anticoagulant effect of heparin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, sclerosing agent, Sodium Tetradecyl Sulfate, Tetradecyl sulfate, varicose veins

Compound Identifiers

PubChem CID

23665770