SNIPER(ABL)-033

SKU: orb1987741

Description

SNIPER(ABL)-033 is a heterobifunctional degrader that conjugates an ABL kinase inhibitor to an IAP ligand. It effectively induces degradation of BCR-ABL protein with a DC50 of 0.3 µM. This compound is a useful research tool for investigating targeted protein degradation in models of chronic myeloid leukemia.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2222354-18-7
• MW: 1211.42
• Formula: C₆₁H₇₃F₃N₁₀O₉S₂
• SMILES: C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(NC=5SC=6C(N5)=CC=C(N6)C7=CC(C(NC8=CC(C(F)(F)F)=C(CN9CCN(CC)CC9)C=C8)=O)=CC=C7)=O)=CC=C4)=CS3)[H]
• Target: Bcr-Abl,Others,SNIPERs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377569