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Catalog Number | orb1822676 |
---|---|
Category | Antibodies |
Description | TATA-box binding protein (TBP) interactions with TBP-associated factors (TAFs) are required for the transcription of RNA polymerases. One particular TBP-TAF complex, snRNA-activating protein complex (SNAPC), is unusual in that it regulates basal transcription of both RNA polymerase II and III by binding specifically to a non-TATA-box proximal sequence element (PSE). SNAPC consists of five subunits of varying size. SNAPC binds to Oct-1 and TBP, which are activators of snRNA and RNA polymerases, respectively. The POU domain of Oct-1 binds to SNAPC 190 and effectively recruits SNAPC to the PSE. The cooperative binding of SNAPC and Oct-1 to their respective sequence elements is mediated by a nucleosome positioned between the two sequence elements. SNAPC 19 mediates the assembly of the subunits to form a functional SNAPC transcription regulator. SNAPC 50 (also designated PTFbeta) contains two zinc finger motifs and binds to SNAPC 43 (also designated PTFGamma) but not SNAPC 45 (PTFdelta). |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | PCRP-SNAPC4-3A7 |
Tested applications | FACS |
Reactivity | Human |
Isotype | Mouse IgG2b, kappa |
Immunogen | Recombinant full-length human protein was used as the immunogen for the SNAPC4 antibody. |
Dilution range | Flow cytometry: 1-2ug/million cells |
Conjugation | Unconjugated |
Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
Hazard Information | This SNAPC4 antibody is available for research use only. |
UniProt ID | Q5SXM2 |
Storage | Aliquot the SNAPC4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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