Smurf1-IN-A01

SKU: orb1307737

Description

Smurf1-IN-A01 is a potent small molecule inhibitor of the Smurf1 ubiquitin ligase (Kd = 3.664 nM). By blocking Smurf1-mediated degradation of Smad1/5, it enhances cellular BMP-2 signaling and is a valuable research tool for studying bone morphogenetic protein pathways in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1007647-73-5
• MW: 512.93
• Purity: 99.54% (May vary between batches)
• Formula: C₂₂H₂₀ClF₃N₄O₃S
• SMILES: Cc1ccnn1-c1ccc(cc1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccc(Cl)c(c1)C(F)(F)F
• Target: MyD88,Others,NF-κB,Estrogen Receptor/ERR,HSP,Interleukin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM);DMSO:62.5 mg/mL (121.85 mM)

Bioactivity

• Target IC50:
  SMURF1:(kd)3.664 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A01, Smurf1, Smurf1 IN A01, Smurf1INA01, Smurf-1-IN-A01, Smurf1-IN-A01

Compound Identifiers

PubChem CID

17555704