Smurf1-IN-A01

SKU: orb1219198

Description

Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1007647-73-5
• MW: 512.93
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₀ClF₃N₄O₃S
• SMILES: CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F
• Target: Smurf1
• Solubility: DMSO:62.5 mg/mL (121.85 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: retinal degeneration model mice. Dosage: 10 μM, 2μL. Administration: Injected into vitreous cavity by micro-syringe. Result: Reduced drusen-like spots. Resulted outer nuclear layers wider and straighter. Caused inner segment and outer segment hinge of photoreceptor cells disappeared. Down-regulated NLRP3 and inhibited IL-1β.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A01

Quick Database Links

Gene Symbol

Smurf1