SMER-28

SKU: orb1225353

Description

A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF; enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.

Key Properties

• CAS Number: 307538-42-7
• MW: 264.1212
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₀BrN₃
• SMILES: C=CCNC1=C2C=C(Br)C=CC2=NC=N1
• Target: Autophagy
• Solubility: DMSO: ≥ 32 mg/mL

Bioactivity

• In Vivo:
  SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg. Animal model: 14 to 16 weeks male mice (Balb/c). Dosage: 15, 65 mg/kg. Administration: Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days). Result: Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.
• In Vitro:
  SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability. Cell Viability Assay Cell line: MMS1 cells. Concentration: 5, 25, 50, 75, 100, 150, 200 μM. Incubation time: 24 hours. Result: Showed a dose dependent decline of cell viability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SMER28

Quick Database Links

Gene Symbol

Autophagy