SL327

SKU: orb1305134

Description

SL327 is a potent and selective MEK1/2 inhibitor with IC50 values of 0.18 μM and 0.22 μM, respectively. Its ability to cross the blood-brain barrier makes it a valuable tool for investigating the MAPK/ERK pathway in both cellular assays and in vivo models of neurological diseases.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 305350-87-2
• MW: 335.35
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₂F₃N₃S
• SMILES: NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F
• Target: MEK,DNA/RNA Synthesis
• Solubility: Ethanol:16.8 mg/mL (50.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.96 mM);DMSO:50 mg/mL (149.1 mM)

Bioactivity

• Target IC50:
  MEK2:0.22 μM|MEK1:0.18 μM
• In Vivo:
  SL327 does not inhibit a variety of other kinases, including PKA, PKC, or CamKII.
• In Vitro:
  Administration of 30 mg/kg of SL327 significantly impairs spatial learning and memory in mice. At a higher dose of 50 mg/kg, SL327 can cross the blood-brain barrier and inhibit conditioned fear by suppressing the phosphorylation of MAPK/ERK.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SL327, SL-327, SL 327, RNA Synthesis, RNASynthesis, inhibit, Mitogen-activated protein kinase kinase, Inhibitor, MAPKK, MAP2K, MEK, MEK2, MEK1, DNA Synthesis, DNASynthesis, AP-1

Compound Identifiers

PubChem CID

24906275