SL-327

SKU: orb1222389

Description

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.

Key Properties

• CAS Number: 305350-87-2
• MW: 335.35
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂F₃N₃S
• SMILES: c1ccc(c(c1)C(=C(N)Sc1ccc(cc1)N)C#N)C(F)(F)F
• Target: AP-1| MEK1| MEK2
• Solubility: DMSO : 68 mg/mL 202.77 mM; Ethanol : 0.1 mg/mL 0.30 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SL327 | SL 327 | SL-327

Quick Database Links

Gene Symbol

AP-1| MEK1| MEK2