SKF38393 HCl

SKU: orb1221940

Description

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

Key Properties

• CAS Number: 62717-42-4
• MW: 291.77
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇NO₂·HCl
• SMILES: Cl.OC1=C(O)C=C2C(CNCCC2=C1)C1=CC=CC=C1
• Target: AChR
• Solubility: DMSO : ≥ 34 mg/mL; 116.53 mM

Bioactivity

• In Vivo:
  SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced depletion of glutathione. SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine. SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline. SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action. Animal model: Balb/c mice (20-25 g). Dosage: 5 mg/kg, 10 mg/kg. Administration: Intraperitoneal injection. Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
• In Vitro:
  SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP. SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells. Western blot analysis. Cell line: GC cells. Concentration: 10 μmol/L. Incubation time: 1 hour. Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(±)-SKF-38393 hydrochloride | SKF-38393A

Quick Database Links

Gene Symbol

AChR