SKF 38393 hydrochloride

SKU: orb1300284

Description

SKF 38393 hydrochloride is a selective agonist for dopamine D1 and D5 receptors. It is widely used in neuroscience research to investigate dopaminergic signaling, including in vitro receptor studies and in vivo models of behaviors such as locomotion and reward.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62717-42-4
• MW: 291.77
• Purity: 99.51%
• Formula: C₁₆H₁₇NO₂·HCl
• SMILES: Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1O
• Target: Dopamine Receptor
• Solubility: Ethanol:6 mg/mL (20.56 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:62.5 mg/mL (214.21 mM);10% DMSO+90% Saline:2 mg/mL (6.85 mM)

Bioactivity

• Target IC50:
  D1:110 nM
• In Vivo:
  SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
• In Vitro:
  SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D5 receptor, D1, Dopamine, Dopamine Receptor, DopamineReceptor, (±)-SKF-38393 hydrochloride, Inhibitor, inhibit, SKF 38393, SKF 38393 Hydrochloride, SKF 38393 hydrochloride, SKF-38393, SKF38393 HCl, SKF38393 Hydrochloride, SKF-38393 Hydrochloride, SKF-38393A, SKF38393

Compound Identifiers

PubChem CID

147514