Cart summary

You have no items in your shopping cart.

Skepinone-L

SKU: orb1223384

Description

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM).

Images & Validation

Key Properties

CAS Number1221485-83-1
MW425.42
Purity>98% (HPLC)
FormulaC24H21F2NO4
SMILESc12c(C(=O)c3c(CC1)ccc(c3)OC[C@@H](CO)O)ccc(c2)Nc1c(cc(cc1)F)F
TargetDehydrogenase
SolubilityDMSO : ≥ 50 mg/mL 117.53 mM; H2O : < 0.1 mg/mL

Bioactivity

In Vitro
Skepinone-L (CBS3830), the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Skepinone-L

Similar Products

  • Skepinone-L [orb1301048]

    >99.99% (May vary between batches)

    1221485-83-1

    425.42

    C24H21F2NO4

    2 mg, 10 mg, 5 mg, 1 mg, 100 mg, 1 ml x 10 mM (in DMSO), 25 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Skepinone-L (orb1223384)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 310.00
50 mg
$ 450.00
100 mg
$ 660.00