SIRT5 inhibitor 5

SKU: orb1744774

Description

This compound is a selective, substrate-competitive SIRT5 inhibitor (IC50 = 210 nM) that acts independently of the NAD+ binding site. It is a valuable chemical probe for investigating the roles of SIRT5 in cancer biology, metabolic disorders, and for conducting both in vitro and in vivo experimental studies.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2883730-60-5
• MW: 423.87
• Purity: 99.33% (May vary between batches)
• Formula: C₂₁H₁₄ClN₃O₃S
• SMILES: O=C(O)C1=CC=C(C=C1)C=C2C(=O)N(N=C2C)C3=NC(=CS3)C=4C=CC(Cl)=CC4
• Target: Sirtuin

Bioactivity

• Target IC50:
  SIRT5:0.21 μM
• In Vitro:
  SIRT5 inhibitor 5(0-10 µM) exhibits consistent inhibitory activity across varying concentrations of NAD+ (50, 100, 200, 400, 800 µM) and shows reduced inhibitory potency with increasing concentrations of Ac-K(Suc)-AMC (10, 30, 90, 270 µM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642412