Et-29

SKU: orb1304104

Description

Et-29 is a potent and selective small molecule inhibitor of SIRT5, exhibiting a Ki value of 40 nM. This compound is a valuable chemical probe for investigating SIRT5's roles in metabolism and cancer biology in both cellular and animal model studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2166487-23-4
• MW: 666.83
• Purity: 99.52% (May vary between batches)
• Formula: C₃₄H₄₆N₆O₆S
• SMILES: CCOC(=O)CCNC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(C)C
• Target: Sirtuin
• Solubility: 5% DMSO+40% PEG300+5% Tween-80+50% ddH2O:10 mg/mL (15 mM);DMSO:200 mg/mL (299.93 mM)

Bioactivity

• Target IC50:
  SIRT5:40 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Et-29, NRD 167, NRD167, NRD-167, SIRT5

Compound Identifiers

PubChem CID

162641741