SIRT5 inhibitor 2

SKU: orb1688007

Description

SIRT5 inhibitor 2 (compound 49) is a potent and selective inhibitor of SIRT5 deacetylase activity with an IC50 of 2.3 µM. This tool compound enables the investigation of SIRT5's role in metabolic reprogramming and cellular stress responses, supporting research in oncology and neurodegenerative disease models both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 340306-87-8
• MW: 407.27
• Purity: 99.88% (May vary between batches)
• Formula: C₁₈H₁₂Cl₂N₂O₃S
• SMILES: O=C1NC(=S)N(C(=O)C1=CC=2OC(=CC2)C=3C=CC=C(Cl)C3Cl)CC=C
• Target: Sirtuin

Bioactivity

• Target IC50:
  SIRT5:2.3 μM
• In Vitro:
  SIRT5 inhibitor 2 (compound 49) is a selective inhibitor of SIRT5, showing an IC₅₀ of 2.3 μM. SIRT5 inhibitor 2 effectively blocks SIRT5-mediated desuccinylation and is applicable in studies related to cancer and neurodegenerative disorders .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1359163