SIRT-IN-2

SKU: orb1309094

Description

SIRT-IN-2 is a potent small molecule inhibitor of SIRT1, SIRT2, and SIRT3 with IC50 values of 4, 1, and 7 μM, respectively. It is a valuable research tool for studying sirtuin biology in cellular models and has been utilized in investigations of cancer, metabolic disorders, and neurodegenerative diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1431411-66-3
• MW: 383.49
• Purity: 98.26% (May vary between batches)
• Formula: C₁₅H₂₁N₅O₃S₂
• SMILES: CS(=O)(=O)NCCC1CCN(CC1)c1ncnc2cc(sc12)C(N)=O
• Target: Sirtuin
• Solubility: 10% DMSO+90% Saline:2.5 mg/mL (6.52 mM);DMSO:62.5 mg/mL (162.98 mM)

Bioactivity

• Target IC50:
  SIRT3:7 nM|SIRT1:4 nM|SIRT2:1 nM
• In Vitro:
  SIRT-IN-2 is one of the most potent truncated pan SIRT1/ 2/3 inhibitor(IC50 values are 4, 4, 7 μM, respectively). SIRT-IN-2 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Sirtuin, SIRT2, SIRT3, SIRTIN2, SIRT-IN-2, SIRT IN 2, SIRT1

Compound Identifiers

PubChem CID

71304815