SIRT-IN-2

SKU: orb1218817

Description

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).

Key Properties

• CAS Number: 1431411-66-3
• MW: 383.49
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₁N₅O₃S₂
• SMILES: CS(NCCC(CC1)CCN1c1ncnc2c1sc(C(N)=O)c2)(=O)=O
• Target: Sirtuin
• Solubility: DMSO:62.5 mg/mL (151.24 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS= 0.29), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sirtuin