Sinensetin

SKU: orb1302364

Description

Sinensetin, a polymethoxylated flavone found in citrus, exhibits antiangiogenic and anti-inflammatory properties. Research indicates it modulates lipid metabolism by promoting adipogenesis and lipolysis, making it a compound of interest for metabolic and inflammatory disease studies in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2306-27-6
• MW: 372.37
• Purity: 97.74% (May vary between batches)
• Formula: C₂₀H₂₀O₇
• SMILES: COc1ccc(cc1OC)-c1cc(=O)c2c(OC)c(OC)c(OC)cc2o1
• Target: TNF,PGE Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.69 mM);DMSO:25.79 mg/mL (69.26 mM)

Bioactivity

• In Vivo:
  Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish.
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• In Vitro:
  Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, hPGDS, Sinensetin, TNFR, TNF Receptor, PGE synthase, PGE Synthase, PGESynthase, Pedalitin permethyl ether, Prostaglandin E synthase, Tumor Necrosis Factor Receptor

Compound Identifiers

PubChem CID

145659