Sinensetin

SKU: orb1222491

Description

Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.

Key Properties

• CAS Number: 2306-27-6
• MW: 372.37
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₀O₇
• SMILES: COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(cc3O2)OC
• Target: hPGDS/Others
• Solubility: DMSO : 12.5 mg/mL 33.57 mM

Bioactivity

• In Vivo:
  Animal model: Carrageenan-induced paw edema in male C57BL/6 mice. Dosage: 50 mg/kg, single dose. Administration: Intraperitoneal injection (i.p.). Result: Sloewd the volume increased of the carrageenan-treated paw at 6 h.
• In Vitro:
  Western blot analysis. Cell line: 3T3-L1. Concentration: 2, 10, 40 μM. Incubation time: 24 d. Result: Increased cellular lipid accumulation and triglyceride content in a dose-dependent manner. Increased the expression of PPARγ1, PPARγ2, C/EBPα, and aP2.Cell Proliferation Assay Cell line: CCRF-CEM cell, Jurkat. Concentration: 6.25-100 μM Incubation time: 24 or 48 h. Result: Inhibited cell viability with different concentrations of sinensetin for 24 h and 48 h. Apoptosis Analysis Cell line: Jurkat cell. Concentration: 50 μM, 100 μM. Incubation time: 24 h and 48 h. Result: Induced a sub-G1 population and apoptotic.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pedalitin permethyl ether

Quick Database Links

Gene Symbol

hPGDS/Others