Simotinib

SKU: orb1694203

Description

Simotinib (AL-6802) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 19.9 nM. It demonstrates anti-tumor activity in non-small cell lung cancer (NSCLC) research, showing efficacy in both in vitro cellular assays and in vivo xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 944258-89-3
• MW: 500.95
• Purity: 99.70% (May vary between batches)
• Formula: C₂₅H₂₆ClFN₄O₄
• SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN1CC2(CC2)C2(C1)OCCO2
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2 mM);DMSO:10 mg/mL (19.96 mM)

Bioactivity

• Target IC50:
  EGFR:19.9 nM
• In Vivo:
  Multiple doses of sunitinib reduced rat body weight by decreasing food intake, similar to human patients, indicating adverse effects of sunitinib on the gastrointestinal tract.
• In Vitro:
  In vitro studies have shown that sunitinib inhibits the growth of EGFR and EGFR-overexpressing human A431 tumor cells in a dose-dependent manner, with no significant activity against other kinases examined in the study.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Simotinib, SIM-6802, AL-6802, EGFR

Compound Identifiers

PubChem CID

16735117