Silybin B

SKU: orb1684217

Description

Silybin B is a flavonolignan that inhibits raloxifene glucosalylation and exhibits antioxidant, anti-fibrinogenic, and neuroprotective activities. It has demonstrated protective effects against cisplatin-induced neurotoxicity in vivo and induces apoptosis in human chronic myeloid leukemia K562 cells in vitro.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 142797-34-0
• MW: 482.44
• Purity: 99.99%
• Formula: C₂₅H₂₂O₁₀
• SMILES: COc1cc(ccc1O)[C@@H]1Oc2cc(ccc2O[C@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
• Target: Bcr-Abl,Apoptosis,Beta Amyloid
• Solubility: DMSO:225 mg/mL (466.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.36 mM)

Bioactivity

• In Vivo:
  Silybin B markedly improve the behavioral abnormalities in cisplatin-treated mice and reduced LPO levels while increasing SOD, GSH, and T-AOC in mice brain tissue. Nissl staining and Tunel assay showed that silybin B alleviated cisplatin-induced hippocampal damage
• In Vitro:
  The present study assesse the effects o the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth Inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects o the production of intracellular Reactive oxygen species and Ca2+

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ROS, Silybin B, Silibinin B, β Amyloid, βAmyloid, BetaAmyloid, Beta Amyloid, DPPH, bAmyloid, b Amyloid, amyloid-β, Apoptosis, BcrAbl, Bcr-Abl (K562 cell line), Calcium Channel

Compound Identifiers

PubChem CID

1548994