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SIK-IN-1

SKU: orb2565291

Description

SIK-IN-1 (Compound 53) is a highly potent, pan-SIK inhibitor with single-digit nM IC50 values against SIK1, SIK2, and SIK3. It modulates macrophage cytokine profiles by potently suppressing TNFα release and enhancing LPS-induced IL-10 production, making it a valuable tool for studying immunometabolism and inflammation in cellular models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number3033846-29-3
MW432.54
FormulaC23H24N6OS
SMILESC(#N)C=1N2C(=CN=C2C=CC1NC)C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3
TargetAMPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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SIK-IN-1 (orb2565291)

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