SIK-IN-3

SKU: orb3134169

Description

SIK-IN-3 (Compound 6B) is an inhibitor of salt-induced kinases (SIK), demonstrating inhibitory effects on SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.3, and 0.8 nM respectively. SIK-IN-1 inhibits TNFa release in human macrophages with an IC50 of 0.6 nM and stimulates LPS-induced IL-10 release with an EC50 of 3 nM.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• Formula: C₂₄H₂₅N₅OS
• Target: AMPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AMPK