SHH (C2) Antibody, Rabbit Polyclonal

• Catalog Number: orb66795
• Category: Antibodies
• Description: Rabbit polyclonal to SHH.Sonic hedgehog (SHH) protein is instrumental in the development of all known animals. In theembryo, it is the key signal in patterning of the ventral neural tube, the anterior-posterior limb axis, andthe ventral somites. In the adult it controls stem cell proliferation. It binds to the patched (PTC)receptor, which functions in association with smoothened (SMO) to activate the transcription of genes.Disruption in SHH signaling during development either through defects in the protein, or maternalteratogen consumption can lead to developmental disorders such as holoprosencephaly (HPE).Abberant activation of the SHH signaling pathway is associated with several types of cancer.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: C-terminal region of human SHH
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 50
• UniProt ID: Q15465
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-SHH antibody,anti-HHG1 antibody,anti-HLP3 ant
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from mouse liver using SHH antibody