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Semaxinib
Catalog Number: orb1306586
| Catalog Number | orb1306586 |
|---|---|
| Category | Small Molecules |
| Description | Semaxinib |
| Purity | 99.84% |
| MW | 238.28 |
| Biological Activity | Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR than PDGFRβ, lack of activity against InsR, EGFR, and FGFR. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. |
| CAS Number | [204005-46-9] |
| Formula | C15H14N2O |
| SMILES | C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C |
| Storage | -20°C |
| Note | For research use only |
(Z)-Semaxinib [orb1305395]
99.94%
[194413-58-6]
238.28
C15H14N2O
50 mg, 25 mg, 10 mg, 5 mg, 1 mg, 200 mg, 100 mg, 1 ml x 10 mM (in DMSO)
