Semapimod

SKU: orb1944285

Description

Semapimod is a small molecule that potently inhibits TLR4 signaling (IC50 ~0.3 µM) and suppresses proinflammatory mediators like TNF-α, IL-1β, IL-6, and nitric oxide. Its mechanism, involving p38 MAPK inhibition, supports its research application in models of sepsis, rheumatoid arthritis, and inflammatory bowel disease both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 352513-83-8
• MW: 744.9
• Formula: C₃₄H₅₂N₁₈O₂
• SMILES: C(=NNC(=N)N)(C)C1=CC(C(=NNC(=N)N)C)=CC(NC(CCCCCCCCC(NC2=CC(C(=NNC(=N)N)C)=CC(C(=NNC(=N)N)C)=C2)=O)=O)=C1
• Target: p38 MAPK,Interleukin,Others,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

492132