Scoulerine

SKU: orb1297212

Description

Scoulerine is a small molecule BACE1 inhibitor and a potent antimitotic agent. It suppresses cancer cell proliferation by arresting the cell cycle and inducing apoptosis, making it a candidate for research in oncology and neurodegenerative disease models, both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 6451-73-6
• MW: 327.37
• Purity: 99.99% (May vary between batches)
• Formula: C₁₉H₂₁NO₄
• SMILES: [H][C@@]12Cc3ccc(OC)c(O)c3CN1CCc1cc(OC)c(O)cc21
• Target: Beta-Secretase,Parasite,Microtubule Associated,Apoptosis,BACE

Bioactivity

• In Vitro:
  Forty-six isoquinoline alkaloids, of eleven structural types isolated in our laboratory, have been evaluated for their cytotoxicity against two cancer cell lines (Caco-2 and Hep-G2 cancer cells), as well as against normal human lung fibroblast cells. Only Scoulerine, aromoline, berbamine and parfumidine showed significant cytotoxic effects, but only Scoulerine was active against both Caco-2 and Hep-G2 cells (IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively). Unfortunately, except for parfumidine, the other active alkaloids were also cytotoxic to the normal human lung fibroblast cells

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antifection, Apoptosis, BACE1, BACE, BetaSecretase, Beta-secretase, bSecretase, b-Secretase, cancer, cycle, division, Discretamine, cells, P. falciparum, mitotic, microtubule, Microtubule/Tubulin, Inhibitor, inhibit, leukemic, Scoulerine, proliferation, β-Secretase, βSecretase

Compound Identifiers

PubChem CID

439654