Schizandrin B

SKU: orb1224462

Description

Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart.

Key Properties

• CAS Number: 61281-37-6
• MW: 400.46
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈O₆
• SMILES: COC1=C(OC)C(OC)=C2C(CC(C)C(C)CC3=CC4=C(OCO4)C(OC)=C23)=C1
• Target: ATM/ATR
• Solubility: Ethanol: 10 mg/mL (24.97 mM); DMSO: 80 mg/mL (199.77 mM)

Bioactivity

• In Vivo:
  Animal model: Mice endotoxic shock model. Dosage: 80 mg/kg. Administration: Intraperitoneally injected (i.p.), single dose. Result: Decreased proliferation and secretion of the proinflammatory cytokines IL-2, IL-6, and IFN-g.
• In Vitro:
  Real Time qPCR Cell line: lymphocyte. Concentration: 10-50 μM. Incubation time: 4 h. Result: Increase in relative mRNA copy number of Nrf2, HO-1, TrxR1, and GCLC. Increased basal ROS levels and decreased GSH/GSSG ratio.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wuweizisu B

Quick Database Links

Gene Symbol

ATM/ATR