Schisandrin B

SKU: orb1304837

Description

Schisandrin B

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 61281-37-6
• MW: 400.46
• Purity: 99.02% (May vary between batches)
• Formula: C₂₃H₂₈O₆
• SMILES: COc1cc2C[C@H](C)[C@H](C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
• Target: ATM/ATR|||Reactive Oxygen Species|||Autophagy
• Solubility: Ethanol:10 mg/mL (24.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.99 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:100 mg/mL (249.71 mM)

Bioactivity

• Target IC50:
  ATR:7.25 μM
• In Vivo:
  Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

gamma-Schisandrin, ATM, Autophagy, ATR, Schizandrin B, Sch B, Schisandrin B, Schisandrin B (Sch B), Reactive Oxygen Species, Wuweizisu B, Wuweizisu-B, ReactiveOxygenSpecies, γ-Schisandrin

Compound Identifiers

PubChem CID

174277