Schisandrin B

SKU: orb1304837

Description

Schisandrin B

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 61281-37-6
• MW: 400.46
• Purity: 99.75%
• Formula: C₂₃H₂₈O₆
• SMILES: COc1cc2C[C@H](C)[C@H](C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
• Target: ATM/ATR,Reactive Oxygen Species,Autophagy
• Solubility: Ethanol:10 mg/mL (24.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.99 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:100 mg/mL (249.71 mM)

Bioactivity

• Target IC50:
  ATR:7.25 μM
• In Vivo:
  Schi andrin B can protect liver against toxicant challenge. Schi andrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. [7] Further studies demonstrat the Protective effect of schi andrin B on free radical-induced damage in various vital organs, includin the heart, liver, kidney, brain and skin. [8] Moreover, schi andrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition a the step of local invasion. [9]

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

gamma-Schisandrin, ATM, Autophagy, ATR, Schizandrin B, Sch B, Schisandrin B, Schisandrin B (Sch B), Reactive Oxygen Species, Wuweizisu B, Wuweizisu-B, ReactiveOxygenSpecies, γ-Schisandrin

Compound Identifiers

PubChem CID

174277