Schisandrin

SKU: orb1940975

Description

Schizandrin is a bio-active isolate of Schisandra chinensis that has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2).(In Vitro):Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.Schisandrin inhibits the SK-HEP-1, SNU-638, and T47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively.Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.(In Vivo):Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.

Key Properties

• CAS Number: 7432-28-2
• MW: 432.51
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₂O₇
• SMILES: c12c(c3c(C[C@@H]([C@](C1)(O)C)C)cc(c(c3OC)OC)OC)c(c(c(c2)OC)OC)OC
• Target: Others
• Solubility: DMSO : 1 mg/mL 2.31 mM

Bioactivity

• In Vivo:
  Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice. Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats. Animal model: Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw. Dosage: 100, 200 mg/kg. Administration: A single i.p. Result: Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.
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• In Vitro:
  Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells. Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages. Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively. Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance. Cell Viability Assay Cell line: RAW 264.7 macrophages Concentration: 12.5, 25, 50, 100 μM Incubation time: Pretreated for 2 h and then incubated with LPS (1 μg/mL) for 18 h. Result: Markedly decreased iNOS protein expression a dose-dependent manner. Significantly inhibited COX-2 protein expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Schizandrin | Gomisins | Magnolia Vine | Omija

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Gene Symbol

Others