SC75741

SKU: orb1300578

Description

SC75741 is a potent and selective small molecule inhibitor of the NF-κB subunit p65 (RelA), exhibiting an IC50 of 200 nM. It is widely used in vitro to study NF-κB signaling in inflammation and oncology, and has been utilized in vivo models to investigate its therapeutic potential.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 913822-46-5
• MW: 565.67
• Purity: 99.82% (May vary between batches)
• Formula: C₂₉H₂₃N₇O₂S₂
• SMILES: O=C(Nc1nc2ccc(cc2[nH]1)C(=O)c1ccccc1)c1csc(n1)C1CCN(CC1)c1ncnc2ccsc12
• Target: NF-κB,Influenza Virus
• Solubility: DMSO:50 mg/mL (88.39 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.54 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  NF-κB:200 nM(EC50)
• In Vivo:
  SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.
• In Vitro:
  SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.
• Cell Research:
  Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SC75741, SC-75741, SC 75741, Inhibitor, NF-κB, NFκB, NF-kB, NFkB, Nuclear factor-κB, Nuclear factor-kappaB, P65, inhibit, InfluenzaVirus, Influenza Virus

Compound Identifiers

PubChem CID

23661638