SC75741

SKU: orb1222999

Description

SC75741 is a NF-kappaB inhibitor. SC75741 protects mice against highly pathogenic avian influenza A virus. SC75741 significantly protects mice against infection with highly pathogenic avian influenza A viruses of the H5N1 and H7N7 subtypes. SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance.(In Vitro):SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation.SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65 hours.SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection.(In Vivo):SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice.The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed.

Key Properties

• CAS Number: 913822-46-5
• MW: 565.67
• Purity: >98% (HPLC)
• Formula: C₂₉H₂₃N₇O₂S₂
• SMILES: O=C(NC1=NC2=CC=C(C=C2N1)C(=O)C1=CC=CC=C1)C1=CSC(=N1)C1CCN(CC1)C1=C2SC=CC2=NC=N1
• Target: GPR
• Solubility: DMSO : ≥ 125 mg/mL; 220.98 mM

Bioactivity

• In Vivo:
  SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice. The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i. v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed. Animal model: Inbred female C57BL/6 mice at the age of 6-8 weeks. Dosage: 15 mg/kg. Administration: Intraperitoneal injection; for 2 days. Result: Reduced the amount of viral mRNA by 90%. Animal model: Inbred female C57BL/6 mice at the age of 6-8 weeks. Dosage: 5 mg/kg or 15 mg/kg. Administration: Intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; 3.5 and 6 hours. Result: Half-life was roughly 40 min and 55 min for i. v. and i.p. administration, respectively.
• In Vitro:
  SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation. SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65 hours. SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection. Cell Proliferation Assay Cell line: A549 cells. Concentration: 5 μM. Incubation time: 24, 48, 72 and 96 hours. Result: Inhibited long-term cell proliferation Cell Viability Assay Cell line: A549 cells. Concentration: 1, 2, 5 or 10 μM. Incubation time: 5.5, 29, 50, 65 hours Result: Reduced cells viability in a concentration-dependent manner. Western blot analysis. Cell line: MDCK cells. Concentration: 5 μM. Incubation time: 24 hours. Result: Inhibited cleavage of the effector caspase 3 induced upon H7N7-infection.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SC75741 | SC-75741 | SC 75741

Quick Database Links

Gene Symbol

GPR