SBE13 Hydrochloride

SKU: orb1305840

Description

SBE13 Hydrochloride is a potent and selective PLK1 inhibitor with an IC50 of 0.2 nM, demonstrating no activity against Aurora A or Plk2/3 kinases. It is a valuable chemical probe for studying mitosis and has been utilized in both in vitro and in vivo cancer research models to investigate targeted therapeutic strategies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1052532-15-6
• MW: 479.4
• Purity: 99.18%
• Formula: C₂₄H₂₈Cl₂N₂O₄
• SMILES: Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
• Target: Autophagy,PLK,Apoptosis
• Solubility: DMSO:80 mg/mL (166.88 mM);H2O:4.8 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM)

Bioactivity

• Target IC50:
  PLK1:0.2 nM|PLK3:875 nM
• In Vivo:
  SBE 13 does not impair the cell cycle or proliferation of primary cells, yet it diminishes the proliferation of various cancer cell lines, induces G2/M arrest, and promotes apoptosis. Co-administration of SBE 13 with Enzastaurin synergistically reduces cell proliferation and enhances apoptosis induction in HCT116 (p53-/-) cells.
• Cell Research:
  Cells are treated with SBE13 one day after subculturing. Control cells are incubated with normal culture medium. Concentrations of SBE13 ranged from 1 nM–100 μM. The growth rate of 1 x 105 cells per 6-well is determined by counting cells at 24, 48 and 72 hours after treatment. Cell culture studies are performed in triplicate for each time point.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Apoptosis, inhibit, Inhibitor, PLK2, PLK3, PLK, PLK1, SBE 13, SBE 13 HCl, SBE 13 hydrochloride, SBE 13 Hydrochloride, SBE13, SBE-13, SBE13 Hydrochloride, SBE-13 Hydrochloride, Polo-like Kinase (PLK)

Compound Identifiers

PubChem CID

11948807