SBE 13 hydrochloride

SKU: orb1222901

Description

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).

Key Properties

• CAS Number: 1052532-15-6
• MW: 479.4
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₈Cl₂N₂O₄
• SMILES: Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
• Target: PLK1| PLK2| PLK3
• Solubility: DMSO : ≥ 42 mg/mL; 87.61 mM

Bioactivity

• In Vitro:
  SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18 μM. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SBE13 | SBE 13 | SBE13 | SBE-13 HCl

Quick Database Links

Gene Symbol

PLK1| PLK2| PLK3