SBC-115337

SKU: orb1298220

Description

SBC-115337 is a small molecule inhibitor targeting PCSK9. It is a research tool for studying lipid metabolism and cardiovascular diseases, applicable in both in vitro enzymatic assays and in vivo models of hypercholesterolemia.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 423148-46-3
• MW: 473.48
• Purity: 99.41% (May vary between batches)
• Formula: C₂₉H₁₉N₃O₄
• SMILES: O=C(Nc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2ccccc2o1)c1cc2ccccc2o1
• Target: Serine/threonin kinase
• Solubility: DMSO:10 mg/mL (21.12 mM)

Bioactivity

• Target IC50:
  PSCK9:0.5μM
• In Vitro:
  The potent compound (SBC-115,337) demonstrated an IC50 of 0.6 μM in an in vitro ELISA assay for monitoring PCSK9 binding to recombinant LDLR. All tested compounds did not affect PCSK9 synthesis, processing, or secretion. At 1.2 μM, SBC-115,337 induced more than tenfold upregulation of LDLR in HepG2 cells, increased uptake of fluorescently labeled DiI-LDL, and lowered LDL-c levels in mice on a high-fat diet.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDLR, HepG2, Inhibitor, inhibit, benzofuran, DiI-LDL, SBC 115337, SBC115337, SBC-115337, PSCK9, recombinant, Serine proteases, Ser/Thr Protease, Serine endopeptidases, Serine kinase, potent, Threonine proteases, threoninkinase, Serinekinase, threonin kinase

Compound Identifiers

PubChem CID

1369939