SBC-115337

SKU: orb1218038

Description

SBC-115337 is a PCSK9 inhibitor.

Key Properties

• CAS Number: 423148-46-3
• MW: 473.48
• Purity: >98% (HPLC)
• Formula: C₂₉H₁₉N₃O₄
• SMILES: O=C(C1=CC2=CC=CC=C2O1)NC3=CC=C(C(NC4=CC=C(C5=NC6=CC=CC=C6O5)C=C4)=O)C=C3
• Target: PSCK9
• Solubility: DMSO: 6mg/mL (12.67mM;ultrasonic and warming and heat to 60℃)

Bioactivity

• In Vitro:
  The potent compound (SBC-115, 337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115, 337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PSCK9