SB-3CT

SKU: orb1225411

Description

SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively.

Key Properties

• CAS Number: 292605-14-2
• MW: 306.4
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄O₃S₂
• SMILES: O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O
• Target: MMP
• Solubility: Ethanol: 10 mg/mL warmed (32.63 mM); DMSO: 61 mg/mL (199.08 mM)

Bioactivity

• In Vivo:
  SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice. Animal model: Five-week-old male C. B.-17.SCID mice. Dosage: 50 mg/kg. Administration: IP; every other day; five weeks. Result: Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.
• In Vitro:
  SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant Ki of 400±15 nM. Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Matrix Metalloproteinase-2/9 Inhibitor IV | MMP-2/MMP-9 Inhibitor IV

Quick Database Links

Gene Symbol

MMP