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SB-225002

SKU: orb1225868

Description

A potent, selective non-peptide CXCR2 antagonist with IC50 of 22 nM; displays >150-fold selectivity over CXCR1; potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro; selectively blocks IL-8-induced neutrophil margination in rabbits.

Images & Validation

Key Properties

CAS Number182498-32-4
MW352.1402
Purity>98% (HPLC)
FormulaC13H10BrN3O4
SMILESO=C(NC1=CC=C([N+]([O-])=O)C=C1O)NC2=CC=CC=C2Br
TargetChemokine Receptor
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SB225002

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    98.85%

    182498-32-4

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    C13H10BrN3O4

    25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg
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SB-225002 (orb1225868)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 200.00
50 mg
$ 340.00
100 mg
$ 570.00
200 mg
$ 860.00
500 mg
$ 1,290.00