SB 204741

SKU: orb1305669

Description

SB 204741 is a potent and selective 5-HT2B receptor antagonist, exhibiting a pKi of 7.1. This compound is a valuable research tool for investigating serotonin signaling in cardiovascular function, fibrosis, and neuropsychiatric disorders in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 152239-46-8
• MW: 286.35
• Purity: 99.86% (May vary between batches)
• Formula: C₁₄H₁₄N₄OS
• SMILES: Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
• Target: 5-HT Receptor
• Solubility: Ethanol:< 5.73 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.98 mM);DMSO:50 mg/mL (174.61 mM)

Bioactivity

• Target IC50:
  5-HT2B receptor (human):7.1 (pKi)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-hydroxytryptamine Receptor, 5HT Receptor, 5HTReceptor, affinity, 5-HT2B, 5-HT Receptor, human, Inhibitor, isoproterenol-induced, myocardial, inhibit, Serotonin Receptor, selective, SB 204741, SB204741, SB-204741, remodeling

Compound Identifiers

PubChem CID

3277600