SB 204741

SKU: orb1218759

Description

5-HT2B receptor antagonist.

Key Properties

• CAS Number: 152239-46-8
• MW: 286.35
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄N₄OS
• SMILES: Cc1nsc(NC(Nc(cc2)cc3c2n(C)cc3)=O)c1
• Target: 5-HT Receptor
• Solubility: Ethanol:<5.73mg/ml;DMSO:<28.64mg/ml

Bioactivity

• In Vivo:
  SB-204741 (0.25~1.0 mg/kg; i.p.) induces myocardial remodeling and dose dependently improves hemodynamic and ventricular functions following isoproterenol-induced myocardial injury. SB-204741 bolsters endogenous anti-oxidant enzymes activities, improves cardiac injury markers, NO level and lipid peroxidation level and attenuates TNFα level in isoproterenol-induced myocardial remodeling in rats. SB-204741 (0.5 and 1.0 mg/kg/day) pre-treatment for 28 days significantly amplifies NO level and GSH and SOD activities and attenuates TBARS level following isoproterenol-induced myocardial remodeling. SB-204741 inhibits inflammatory protein expression, upregulates autophagy and HSPs protein expressions in isoproterenol-induced myocardial remodeling in rats. SB-204741 improves myocardial architecture in isoproterenol-induced myocardial remodeling in rats. Animal model: Rats. Dosage: 0.25~1.0 mg/kg. Administration: i.p. Result: Induced myocardial remodeling.
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• In Vitro:
  The most selective 5-HT2B receptor ligand to be tested is SB 204741 with approximately 20 fold selectivity for the human 5-HT2B receptor as compared to the human 5-HT2C receptor.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

5-HT Receptor