Savolitinib

SKU: orb1296129

Description

Savolitinib

Research Area

Signal Transduction

Key Properties

• CAS Number: 1313725-88-0
• MW: 345.36
• Purity: 98.12% (May vary between batches)
• Formula: C₁₇H₁₅N₉
• SMILES: C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1
• Target: c-Met/HGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.79 mM);DMSO:32 mg/mL (92.66 mM)

Bioactivity

• Target IC50:
  pMet:3 nM (cell free)|c-Met:5 nM (cell free)
• In Vivo:
  In a U87MG subcutaneous xenograft model, Savolitinib (1-10.0 mg/kg; oral administration; daily; for 21 days; athymic nude mice) demonstrates dose-dependent tumor growth inhibition. In addition, none of the mice in the dosing groups exhibits body weight loss during the experiment .
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• In Vitro:
  Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways [1,2].
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD 6094, AZD6094, AZD-6094, cMet, c-Met, cMet/HGFR, c-Met/HGFR, Inhibitor, inhibit, HMPL 504, HMPL504, HMPL-504, HGFR, Volitinib, Savolitinib

Compound Identifiers

PubChem CID

68289010