Savolitinib

SKU: orb1220263

Description

Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity.

Key Properties

• CAS Number: 1313725-88-0
• MW: 345.36
• Purity: >98% (HPLC)
• Formula: C??H??N?
• SMILES: CN1N=CC(C2=CN=C3C(N([C@H](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1
• Target: c-Met/HGFR
• Solubility: DMSO : 25 mg/mL (72.39 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Animal model: U87MG xenograft model in athymic nude mice. Dosage: 1 mg/kg, 2.5 mg/kg and 10.0 mg/kg. Administration: Oral administration; daily; for 21 days. Result: Demonstrated dose-dependent tumor growth inhibition in a U87MG subcutaneous xenograft model.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

c-Met/HGFR