Satraplatin

SKU: orb1299965

Description

Satraplatin

Research Area

Molecular Biology

Key Properties

• CAS Number: 129580-63-8
• MW: 500.28
• Purity: 98.25%
• Formula: C₁₀H₂₂Cl₂N₂O₄Pt
• SMILES: [Pt+4]([NH2]C1CCCCC1)([O-]C(C)=O)([O-]C(C)=O)([Cl-])([Cl-])[NH3]
• Target: DNA Alkylation,DNA Alkylator/Crosslinker
• Solubility: DMSO:33 mg/mL (65.96 mM)

Bioactivity

• In Vitro:
  KB-R cells did not show cross-resistance to satraplatin. The expression status of almost all transporters was upregulated in the KB-R cells. There was no difference in the GSH levels between the KB and KB-R cells. Flow cytometric analysis indicated that with satraplatin the G2/M phase was arrested in the KB-R cells. KB-R cells contain enriched side population cells.
• Cell Research:
  CDDP-resistant (KB-R) cells and parental cells (KB) pair were used. Viability was assessed using the MTT and clonogenic assay. Real-time polymerase chain reaction (PCR), glutathione (GSH) assay, and flow cytometric analysis were used for further assessment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNAAlkylation, DNAAlkylator, DNA Alkylator/Crosslinker, DNA Alkylator, DNA Alkylation, DNA Alkylating, Crosslinker, BMY 45594, BMY45594, BMY-45594, BMS182751, BMS-182751, BMS 182751, Inhibitor, inhibit, JM 216, JM216, JM-216, Satraplatin

Quick Database Links

Gene Symbol

DNA Alkylation,DNA Alkylator/Crosslinker