Satraplatin

SKU: orb1226599

Description

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis; shows similar cytotoxicity and pattern of cytotoxicity to cisplatin against human ovarian carcinoma cell lines (IC50=1.7 uM); shows antitumor selectivity far superior to cisplatin, carboplatin, or tetraplatin in vivo; orally active.Chemotherapeutic Agents, Phase 2 Clinical(In Vitro):Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells.

Key Properties

• CAS Number: 129580-63-8
• MW: 500.2816
• Purity: >98% (HPLC)
• Formula: C₁₀H₂₂Cl₂N₂O₄Pt+2
• SMILES: CC(O[Pt]([NH2]C1CCCCC1)(Cl)(Cl)([NH3])OC(C)=O)=O
• Target: DNA Alkylator
• Solubility: DMSO: ≥ 33 mg/mL

Bioactivity

• In Vitro:
  Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state. Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS-182751 | BMY-45594 | JM-216

Quick Database Links

Gene Symbol

DNA Alkylator