SATB1 (N) Antibody, Rabbit Polyclonal

SKU: orb66709

Description

Rabbit polyclonal to SATB1.Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin organizer and transcription factorthat integrates chromatin architecture with gene regulation. SATB1 binds to nuclear matrix/scaffoldassociatingAT-rich DNA sequences (MARs/SARs). It has been shown that SATB1 interacts withpromyelocytic leukemia protein (PML), and that SATB1 and PML function as a regulatory complexthat controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 isimplicated as a key regulator of the differentiation and activation of T cells. In cancer, SATB1 hasbeen shown to reprogram chromatin organization and the transcription profiles of breast tumors topromote growth and metastasis.

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human SATB1
• Molecular Weight: 86
• Purity: Affinity purification

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-SATB1 antibody,anti-OTTHUMP00000207689 antibody,anti-Special ATrich sequencebinding protein 1 antibody

Western blot analysis of total cell extracts from mouse thymus using SATB1 antibody

Quick Database Links

UniProt

Q01826

References

Eleftheriadis, Theodoros et al. Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells Hum Immunol, 74, 1501-1509 (2013)

PubMed: 23993986