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| Catalog Number | orb66709 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to SATB1.Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin organizer and transcription factorthat integrates chromatin architecture with gene regulation. SATB1 binds to nuclear matrix/scaffoldassociatingAT-rich DNA sequences (MARs/SARs). It has been shown that SATB1 interacts withpromyelocytic leukemia protein (PML), and that SATB1 and PML function as a regulatory complexthat controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 isimplicated as a key regulator of the differentiation and activation of T cells. In cancer, SATB1 hasbeen shown to reprogram chromatin organization and the transcription profiles of breast tumors topromote growth and metastasis. |
| Clonality | Polyclonal |
| Species/Host | Rabbit |
| Conjugation | Unconjugated |
| Reactivity | Human, Mouse |
| Buffer/Preservatives | 0.01% NaN3 |
| Purity | Affinity purification |
| Immunogen | N-terminal region of human SATB1 |
| UniProt ID | Q01826 |
| MW | 86 |
| Tested applications | WB |
| Dilution range | WB:1:1000-1:5000 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Alternative names | anti-SATB1 antibody,anti-OTTHUMP00000207689 antibo Read more... |
| Note | For research use only |
Eleftheriadis, Theodoros et al. Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells Hum Immunol, 74, 1501-1509 (2013)
Western blot analysis of total cell extracts from mouse thymus using SATB1 antibody
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